Supplementary Material for: The Ghent Psychotherapy Study (GPS): a pragmatic, stratified, randomized parallel trial into the differential efficacy of psychodynamic and cognitive-behavioral interventions in dependent and self-critical depressive patients

Introduction: Different types of psychotherapy are effective for treating major depressive disorder across groups yet show large within-group differences. Patient personality style is considered a potentially useful variable for treatment matching.
Objective: This study is the first experimental test of the interaction between therapeutic approach and patients’ dependent versus self-critical personality styles.
Methods: A pragmatic stratified parallel trial was carried out with 100 adult patients diagnosed with DSM-IV-TR Major Depressive Disorder. They were randomly assigned to short-term (16–20 sessions) Cognitive Behavioral Therapy (CBT) or Short-Term Psychodynamic Psychotherapy (STPP). Patients were assessed at baseline, during therapy, post therapy, and 3 and 6-month follow-up. Primary outcome is depression severity measured by the Hamilton Rating Scale for Depression post treatment. Primary analysis was by intention to treat. This trial is registered with the ISRCTN registry (www.isrctn.com), number ISRCTN17130982.
Results: The intention-to-treat sample consisted of 100 participants; 40 with self-critical and 60 with dependent personality styles were randomized to either CBT (n=50) or STPP (n=50). We observed no interaction effect (–0·34 (–6·14,5·46)) between therapy and personality style and found no evidence for a difference in effectiveness between the treatments in general in terms of symptom reduction and maintained benefits at 6-month follow-up.
Conclusion: We found no evidence that dependent versus self-critical personality styles moderate the relation between treatment and outcome in depression. Research using individual patient data could gain further insight into why specific therapeutic approaches work better for specific patients.

引言：针对重度抑郁症，不同的心理治疗方法在群体中均表现出有效性，但群体内部差异显著。患者的人格风格被视为治疗匹配中可能具有实用价值的变量。研究目标：本研究是首次对治疗方法和患者依赖型与自我批判型人格风格之间相互作用进行实验性测试。研究方法：进行了一项以100名被诊断为DSM-IV-TR重度抑郁症的成年患者为对象的实用分层平行试验。他们将患者随机分配至短期（16-20次会话）认知行为疗法（CBT）或短期心理动力学心理治疗（STPP）。患者在基线、治疗期间、治疗后以及3个月和6个月的随访中接受评估。主要结局指标为治疗后通过汉密尔顿抑郁量表测量的抑郁严重程度。主要分析采用意向治疗原则。本试验已在ISRCTN登记注册（www.isrctn.com），注册号为ISRCTN17130982。结果：意向治疗样本包括100名参与者；其中40名为自我批判型人格风格，60名为依赖型人格风格，随机分配至CBT（n=50）或STPP（n=50）。我们观察到治疗与人格风格之间无交互作用（–0·34 (–6·14,5·46)），在总体上未发现治疗效果存在差异，即在症状减轻和6个月随访期间维持益处方面。结论：本研究未发现依赖型与自我批判型人格风格调节治疗与抑郁结局之间关系的证据。使用个体患者数据的研究可能进一步揭示为何特定的治疗方法对特定的患者更为有效。