Kaplan Meier time to event analyses for SOD1G93A and double transgenic (SOD1G93A/DAOR199W) in both males and females.

A. Median values obtained from Kaplan-Meier analysis for the time taken for mice to reach a score of 2 in both hindlimbs (onset of neurological scores), age at maximum weight (disease onset), disease progression and time taken for animals to reach the humane end point determined by its inability to right itself within 20 seconds of being placed on its side (survival) for both males and female littermates of either genotype groups. B. The Log-rank test assesses the null hypothesis that the Kaplan-Meier curves for all groups are identical (i.e. the presence of the DAOR199W transgene did not change the time taken to reach the event being analysed). Thus, low P-values (shown below) indicate that differences between genotype groups did not occur due to chance. Log-rank analysis of the onset of neurological symptoms in females carrying the SOD1G93A transgene versus their double transgenic littermates revealed that there were significant differences between the groups for this particular measurement. A significant difference was also detected in survival between the double transgenic males and females via the log-rank test. Significant differences are indicated in bold. Threshold of significance was set at P