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Computational challenges in the analysis of ancient DNA

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NIAID Data Ecosystem2026-03-12 收录
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The identification and quantification of biases introduced by particular characteristics of ancient DNA samples. We demonstrate the importance of closely related genomic sequence for correctly identifying and classifying bona fide endogenous DNA fragments. We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering.

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2021-02-04
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