N-atom dealkylation of caffeine

Caffeine is one of the world's most frequently consumed xenobiotic. The major source of caffeine comes from tea and coffee. Caffeine is extensively metabolized in humans with at least 17 metabolites formed in its biotransformation. CYP1A2 is a prominent enzyme in the formation of an important metabolite of caffeine (paraxanthine) by N3-demethylation.

咖啡因乃全球范围内消费频率最高的非原生生物之一。其主要来源为茶叶与咖啡。在人体内，咖啡因经历广泛的代谢过程，至少形成17种代谢产物。CYP1A2酶在咖啡因生物转化过程中生成重要代谢物（对羟基苯甲酸）的N3去甲基化反应中扮演着显著角色。