MDM2 in complex with SAR405838
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MDM2 in complex with SAR405838 Descriptor: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... Authors: Meagher, J.L, Stuckey, J.A. Deposit date: 2016-10-26 Release date: 2016-11-09 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res., 74, 2014
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2016-10-26
