TBEVHostDB

TBEVHostDB — a catalog of human genes that are probably involved in response to TBEV infection. It was created based on manual review and curation of scientific publications. If the publication described a non-human mammalian gene/protein, the homologous human gene was found and included into the catalog. At present a catalog contains 140 human genes. Genes are classified into functional categories (datasets) according to five types of evidence: (1) genes encoding proteins that had direct physical interactions with TBE viral particle, TBEV proteins or RNA.; (2) genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection ; (3) allelic variants in these genes are associated with susceptibility or resistance to TBEV infection; (4) these proteins were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity; (5) knockout of these genes in mice increased mortality rates or affected the other clinical manifestations of the disease.