HbA1c as predictor of severe hypoglycemia and hypoglycemic coma per year, expressed as relative risk per 1% HbA1c decrease.

RRs with 95% CIs derived from regression models with severe hypoglycemia or hypoglycemic coma as the dependent variable and using continuous terms for HbA1c and treatment year. Model 1 adjusted for HbA1c, treatment year, sex, age, and diabetes duration, and with a term for interaction between HbA1c and treatment year; model 2 additionally adjusted for insulin treatment regimen (1–3 or ≥4 insulin injection time points per day, or insulin pump therapy). p-Values from Wald tests refer to RRs. Wald test for trend in RR per 1% HbA1c decrease: pHbA1c as predictor of severe hypoglycemia and hypoglycemic coma per year, expressed as relative risk per 1% HbA1c decrease.