ProteinCartography v0.4 analyses for sample of most-studied human proteins

Results from running the ProteinCartography pipeline (v0.4) using analyses on 25 proteins sampled from the most-studied human proteins listed in Liu and Buck, 2021.

The proteins included are listed in the table below. The results for each analysis are provided as individually-zipped folders, with the name of the file reflective of the protein name. To download all of the analyses in one folder, you can download the "25humanprotein_analysis.zip" file.

UniProt ID

Protein name

Protein symbol (in figures)

Q9UM73

ALK tyrosine kinase receptor

ALK

Q96RI1

Bile acid receptor

NR1H4

P43235

Cathepsin K

CATK

P08603

Complement factor H

CFAH

P00374

Dihydrofolate reductase

DYR

P98170

E3 ubiquitin-protein ligase XIAP

XIAP

P49841

Glycogen synthase kinase-3 beta

GSK3B

P01112

GTPase HRas

RASH

P68871

Hemoglobin subunit beta

HBB

P04439

HLA class I histocompatibility antigen, A alpha chain

HLAA

P01834

Immunoglobulin kappa constant

IGKC

P14174

Macrophage migration inhibitory factor

MIF

P53779

Mitogen-activated protein kinase 10

MK10

Q15596

Nuclear receptor coactivator 2

NCOA2

Q99497

Parkinson disease protein 7

PARK7

P62937

Peptidyl-prolyl cis-trans isomerase A

PPIA

Q13451

Peptidyl-prolyl cis-trans isomerase FKBP5

FKBP5

P27986

Phosphatidylinositol 3-kinase regulatory subunit alpha

P85A

O75530

Polycomb protein EED

EED

P28074

Proteasome subunit beta type-5

PSB5

P19793

Retinoic acid receptor RXR-alpha

RXRA

P50120

Retinol-binding protein 2

RET2

P00441

Superoxide dismutase [Ccu-Zn]

SODC

Q93009

Ubiquitin carboxyl-terminal hydrolase 7

UPB7

P40337

von Hippel -–Lindau disease tumor suppressor

VHL

A TSV file, "most_studied_human_proteins.tsv", is included for use with the analysis notebook ("pub/most_studied_human_proteins.ipynb") found in our GitHub repository for the Arcadia Science Pub "ProteinCartography: Comparing proteins with structure-based maps for interactive exploration". The notebook produces the outputs, "sampled_proteins.tsv", and. "most_studied_human_proteins_analysis.tsv", which are used by the analysis notebook ("pub/cluster_quality_human_proteins.ipynb"), which uses the contents of this deposition.