Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2

After recruitment to activated FGFR mutants, FRS2 is believed to be phosphorylated, potentially on all 6 of the tyrosines phosphorylated by wild-type FGFRs. Phosphorylation of FRS2 by FGFR has been demonstrated in some cases (see for instance Qing, 2009; Bai, 2010; Ahmed, 2008; Raffioni, 1998) and is inferred to occur in others based on activation of downstream signaling modules (reviewed in Wesche, 2011; Turner and Grose, 2010; Parker et al, 2014; Carter et al, 2015).

招募至激活的FGFR突变体之后，FRS2被认为被磷酸化，可能涉及野生型FGFRs所磷酸化的所有6个酪氨酸。在某些情况下已证实FGFR对FRS2的磷酸化作用（例如，参见Qing，2009；Bai，2010；Ahmed，2008；Raffioni，1998），而其他情况下则基于下游信号模块的激活进行推断（参见Wesche，2011；Turner和Grose，2010；Parker等，2014；Carter等，2015年的综述）。