Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.
收藏PubMed Central1992-01-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC48210/
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资源简介：
The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-01-01
