Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19. A simulation study
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* Description of the Sample model code Fortran Implementation of the cell model for the human ventricular action potentialThis cell model is used in the article 'Chloroquine and hydroxychloroquine provoke arrhythmiasat concentrations higher than those clinically used to treat COVID-19. A simulation study'by Jun-ichi Okada, Takashi Yoshinaga, Takumi Washio, Kohei Sawada, Seiryo Sugiura and Toshiaki Hisada Programed by Jun-ichi OkadaEmail : okada@fc.u-tokyo.ac.jp This cell model based on the models reported in the following articles.O'Hara, T., Virag, L., Varro, A. & Rudy, Y. PLoS Computational Biology. 7, e1002061 (2011).Dutta, S., Strauss, D., Colatsky, T. & Li, Z. 2016 Computing in Cardiology Conference (CinC). 2016: 869-872.ten Tusscher, K.H.W.J., Noble, D., Noble, P.J. & Panfilov, A.V. Am J Physiol. 286, H1573-H1589 (2004). * Description of the ECG data ECG4.out : Limb lead electrocardiogramColumn1:time[ms], Column2:I-lead[mV], Column3:II-lead[mV], Column4:III-lead[mV], Column5:aVR-lead[mV], Column6:aVL-lead[mV], Column7:aVF-lead[mV], Column8:VR-lead[mV], Column9:VL-lead[mV], Column10:VF-lead[mV] ECG_chest.out : Precordial lead electrocardiogramColumn1:time[ms], Column2:V1-lead[mV], Column3:V2-lead[mV], Column4:V3-lead[mV], Column5:V4-lead[mV], Column6:V5-lead[mV], Column7:V6-lead[mV], Column8:Wilson central terminal[mV]
