IRAK4 in Complex with Compound 18
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IRAK4 in Complex with Compound 18 Descriptor: Interleukin-1 receptor-associated kinase 4, methyl {[(1S,3s)-3-{[(2P)-2-[(8R)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-5-{[(2S)-2-fluoro-3-hydroxy-3-methylbutyl]carbamoyl}pyridin-4-yl]amino}cyclobutyl]methyl}carbamate Authors: Ferrao, R, Lansdon, E.B. Deposit date: 2025-02-11 Release date: 2025-05-28 Last modified: 2025-06-18 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Discovery of Edecesertib (GS-5718): A Potent, Selective Inhibitor of IRAK4. J.Med.Chem., 68, 2025
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2025-02-11
