TEDD

The Temporal Expression during Development Database (TEDD) is an ongoing effort to build a comprehensive public resource to study tissue and temporally specific gene expression and regulation (accessible chromatins) during multiple developmental periods. Data were curated from publicly accessible datasets generated by molecular assays (bulk-sample RNA-seq, scRNA-seq and scATAC-seq) in samples originated from 79 non-diseased tissue sites across nearly 4,000 individuals.发育时序表达数据库（Temporal Expression during Development Database，简称TEDD）是一项持续推进的公共资源构建项目，旨在打造一套全面的公共资源库，用于研究多个发育阶段中组织特异性与时序特异性的基因表达及调控（可及染色质）情况。该数据库的数据均经人工整理，源自公开可获取的分子检测数据集，样本来自近4000名个体的79个非病变组织位点，所用分子检测手段包括批量样本RNA测序（bulk-sample RNA-seq）、单细胞RNA测序（scRNA-seq）以及单细胞转座酶可及性测序（scATAC-seq）。

搜集汇总

背景与挑战

背景概述

TEDD（发育期间时间表达数据库）是一个大规模、多物种的公共资源，整合了来自胚胎、胎儿、新生儿、儿童和成人阶段的转录组和染色质可及性数据。该数据库覆盖超过1520万个细胞、9个物种、85种组织类型和162个时间点，并提供虚拟基因敲除、轨迹推断等分析工具，以支持发育机制研究。