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Metal-Free Trifluoromethylation of Indazoles

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NIAID Data Ecosystem2026-03-10 收录
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A simple and efficient tert-butyl hydroperoxide-mediated direct trifluoromethylation of indazoles using sodium trifluoromethanesulfinate has been developed under metal-free conditions. A library of trifluoromethylated products with broad functionalities has been synthesized with moderate to good yields. A radical mechanistic pathway has been proposed for the present protocol.

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2018-10-21
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