Structural basis of GPCR activation mechanism by using photoswitchable ligand...

B2FIND2026-04-28 收录

偶联受体药理

光控配体激活机制

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https://b2find.eudat.eu/dataset/3edcbfa7-6d14-5fbc-bb1b-6a74a4a82a36 数据链接链接失效反馈

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This project aims at deciphering the structural dynamics of G protein-coupled receptor (GPCRS) seven transmembrane domain (7TM) bound to a photoswitchable ligand and to decipher...

S1P4 First Extracellular Loop Peptidomimetic

偶联受体药理

肽设计

S1P4 First Extracellular Loop Peptidomimetic Descriptor: S1P4 First Extracellular Loop Peptidomimetic Authors: Pham, T.C.T, Kriwacki, R.W, Parrill, A.L. Deposit date: 2006-01-11 Release date: 2007-01-

Protein Data Bank Japan2024-10-16 更新50

cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody

离子通道结构生物学

偶联受体药理

cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1

Protein Data Bank Japan2025-06-04 更新20

Alanine mutagenesis and functional characterization of amino acids in the ICL1 and transitions to the helices 1 and 2.

偶联受体药理

细胞信号传导

COS-7 cells were transfected with wt TSHR or various mutant TSHRs. The vector pcDNA3.1(−) / hygromycin was used as a control. The TSHR is characterized by an elevated cAMP level compared to the contro

NIAID Data Ecosystem10

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization

偶联受体药理

EP2受体拮抗剂

Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comp

NIAID Data Ecosystem30

Additional file 5 of Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum

寄生虫功能基因组

偶联受体药理

Additional file 5: Table S2. Original data table for GPCR classification and ligand prediction in S. japonicum. In the table, the first column is the s.j GPCR genes ID, the second column is the GPCRs

Figshare2025-07-17 更新20

Structural basis of GPCR activation mechanism by using photoswitchable ligand...

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