five

miRNA expression of gefitinib-resistant cell lines

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110815
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To identify novel miRNAs involved in acquired EGFR TKI resistance in NSCLC, genome-wide miRNA expression analysis was performed in gefitinib-resistant sub-cell lines and gefitinib-sensitive parental cell lines. Gefitinib-resistant sub-cell lines were generated by growing gefitinib-sensitive EGFR-mutant NSCLC cell lines (PC9 and HCC827) in increasing concentrations of gefitinib to a final concentration of 10 uM up to 6 months.
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2018-05-23
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