Dynamics of RNA-m5C Modification during Brain Development

In this study we evaluate the changes in m5C methylation at critical post-natal stages of brain development and links to methylation levels of neuronal stem cells and cortical neurons. We identify transcript-specific changes in methylation level associated with gene expression. Analysis of RNA BS-seq and RNAseq data in P0, P17, and 6W whole brain and NSC and E16.5 cortical neuron culture