Oliveira fms et al 2020.pdf

Human ascariasis is
considered the most prevalent neglected tropical disease in the world. The
immune response in human ascariasis is characterized by a Th2 polarization, as
well as a mixed Th2 / Th17 response present in the pathogenesis of experimental
larval ascariasis. Proinflammatory cytokines are essential to induce nitric
oxide synthesis via inducible nitric oxide enzyme expression. Several studies
have shown the participation of nitric oxide in helminth infections such as Brugia malayi, Toxocara canis, Schistosoma
mansoni, Echinococcus granulosus
and Strongyloides venezuelensis, however
its role in ascariasis remains unknown. To elucidade the role of nitric oxide
in ascariasis, C57BL/6 mice iNOS knockout were evaluated during acute infection
of ascaris to report the possible participation of nitric oxide on
parasitological and immunopathological aspects. We reported nitric oxide as a
crucial inflammatory molecule to control the parasite establishment and
development of host immune response to infection in the liver.