Neighbors significantly associated with insulin signaling pathway.

1ACADSB is involved in the metabolism of fatty acids and branch chained amino acids [79]. Prolonged treatment with long chain FFAs, including palmitate, increases FA oxidation [12], [80], which has been proposed to serve as a protective mechanism against the potential toxic effects of long chain fatty acids [80], [81]. Insulin, on the other hand, down-regulates FA oxidation in various cell types [82], [83]. Since palmitate can impair the insulin signaling pathway [84], it is reasonable that ACADSB emerges as a top neighbor of the insulin signaling pathway.