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TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths. TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths

NIAID Data Ecosystem2026-03-13 收录

阿尔茨海默病机制

小胶质细胞信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA864837 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2022-08-01

阿尔茨海默病机制

小胶质细胞吞噬功能

Background: CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferent

NIAID Data Ecosystem30

Table_1_Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF.DOC

阿尔茨海默病机制

针刺调控脑血流

BackgroundThe astrocytic phospholipase A2 (PLA2)-arachidonic acid (AA) pathway is crucial in understanding the reduction of cerebral blood flow (CBF) prior to cognitive deterioration. In complementary

NIAID Data Ecosystem10

Lysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction

阿尔茨海默病机制

溶酶体蛋白质组学

The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abn

NIAID Data Ecosystem00

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

阿尔茨海默病机制

线粒体代谢

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7

NIAID Data Ecosystem20

Data Sheet 1_Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model.docx

阿尔茨海默病机制

饮食诱导神经炎症

IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representa

NIAID Data Ecosystem00

TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths. TREM2 Drives Microglia Response to Amyloid-β via SYK-dependent and -independent Paths

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