Genomic analyses reveal presence of extensively drug-resistant Salmonellaenterica serovars isolated from clinical samplesin Guizhou province, China, 2019-2023

The emergence of extensively drug-resistant (XDR) Salmonella in human represents a serious public health and therapeutic challenge. Our study presents the first data on the WGS-based characterization of XDR Salmonella isolates from humans between 2019 and 2023 in Guizhou province, China. Meanwhile, XDR Salmonella isolates carried multiple ARGs on plasmids, which could promote the acquisition and dissemination of ARGs. Our findings offer significant biological insights into XDR Salmonella resistance mechanisms, and showed that implementing continuous dynamic surveillance will enhance our understanding of the epidemiology of XDR Salmonella in this region and help public health officials identify emerging trends and potential threats.