Powder X-ray Diffraction as an Emerging Method to Structurally Characterize Organic Solids

The current level of laboratory instrumentation and computational resources allows X-ray powder diffraction to be implemented into the
toolbox of organic chemists, providing a means for rapid (i.e., within a day) structural characterization of organic solids, without the need for
single crystals. We illustrate such use of powder diffraction using two case studies of molecular cocrystals of trifluoroacetic acid and malonic
acid, involving theobromine, a model active pharmaceutical ingredient. We also report on a previously unobserved conformation of malonic
acid in the solid state.