Detailed overview of the different protein systems analyzed in this study.

The columns of this table are arranged as follows: (1) the name of each protein studied; (2) the corresponding Protein Data Bank (PDB) ID for each molecule [92]; (3) the known chemical change or mutation type that is considered; (4) the specific structural signatures that are known to be associated with each chemical change or mutation type; (5) the presumed difficulty level for SINATRA Pro to detect each structural signature based on the homogeneity in shape variation between the wild-type and mutant proteins; and (6) references that have previously suggested some level of association or enrichment between each structural change and the mutation of interest.