Asymmetric Total Synthesis and Structural Elucidation of NFAT-68
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https://figshare.com/articles/dataset/Asymmetric_Total_Synthesis_and_Structural_Elucidation_of_NFAT_68/2700139
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Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the syn-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.
创建时间:
2016-02-24



