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Asymmetric Total Synthesis and Structural Elucidation of NFAT-68

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NIAID Data Ecosystem2026-03-06 收录
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Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the syn-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.

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2016-02-24
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