Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Organisation for Economic Co-operation and Development2026-02-07 收录

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This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of...

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

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