Small molecular stabilizer for ERalpha and 14-3-3 (1080299)
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Small molecular stabilizer for ERalpha and 14-3-3 (1080299) Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[(2~{S},6~{R})-4-[(4-chlorophenyl)amino]-2,6-dimethyl-oxan-4-yl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-09-16 Release date: 2023-09-20 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
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2022-09-16
