H3K36me3 protects the mouse epigenome from single nucleotide variations [ChIP-Seq]

We analyze high-throughput profiling of histone H3K36me3 in mouse embryonic stem cells from chromatin immunoprecipitated DNA captured by H3K36me3-specific antibody. We find that H3K36me3 distribution is like expected and enriched at transcribing gene bodies especially with enrichment at 3’-terminal of gene body, which is identical with findings observed in other mammalian cells. Examination of histone H3K36me3 modification in mouse embryonic stem cell with histone H3.1WT overexpression, we analyzed two replicates.