Crystal Structure of Calcineurin Clinical Variant E282K

Crystal Structure of Calcineurin Clinical Variant E282K Descriptor: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... Authors: Parikh, T, Shirakawa, K.T, Page, R, Peti, W. Deposit date: 2025-03-25 Release date: 2025-12-17 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (2.09 Å) Cite: The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment. Nat Commun, 17, 2026