Average daily number of neratinib tablets administered each week by treatment group over the 4-week crofelemer study period in neratinib-induced diarrhea in dogs (n = 8 per treatment group).

Diarrhea was induced by daily doses of neratinib. Dogs were dosed with one tablet (40 mg) of neratinib orally once daily for the first 5 days followed by once daily doses of two tablets (80 mg) of neratinib for the remaining 23 days of the 28-day study. Treatment groups were defined as a placebo-controlled group (CTR) receiving placebo capsules orally four times a day, crofelemer (125mg) administered orally twice daily (BID), and crofelemer (125mg) administered orally four times a day (QID) for 28 days.