Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice
收藏PubMed Central1997-04-01 更新2026-04-25 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC20378/
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资源简介：
Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α-calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in αCaMKII (−/−) mice is conditional, with the relevant condition being postnatal age.
提供机构：
National Academy of Sciences
创建时间：
1997-04-01
