Lipidation of brush polyethylene glycol polymers to extend plasma half-life and promote lymphatic uptake

This thesis evaluated the properties of novel drug carriers linked to different fatty materials. This led to the association of the carriers with natural fat transporters including albumin and lipoproteins. Consequently, this association resulted in distinct uptake of the drug carriers by specific organs such as lymph nodes, and also different exposure of the drug carriers in blood. Collectively, this thesis suggests that these drug carriers might be utilised to deliver therapeutic molecules to certain organs such as lymph nodes to diagnose or treat diseases such as cancers and infections, which can maximise the efficacy of drugs and minimise their toxicity.