p53 Signaling in SH-SY5Y (SY) Cells.

Changes in p53 Signaling gene expression indicate a microglial cell-induced shift in the state of SY cells co-cultured with B. burgdorferi (Bb) from one of cell survival and proliferation, toward one of apoptosis and cell cycle arrest. Changes noted with a single asterisk represent a pro-apoptotic shift while those shown with a double asterisk suggest preparation for cell cycle arrest at G1/S.