Homo sapiens RNAseq data on systemic perturbation of keratinocyte homeostasis by genetic loss of the extracellular matrix protein collagen VII. Homo sapiens

The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and plays a critical role in organismal homeostasis. Its genetic loss is linked to skin fragility and progressive injury- and inflammation-driven fibrosis that ultimately results in aggressive skin cancer. Because epithelial dysfunction is a principle initiator of fibrosis in other diseases, we performed comprehensive transcriptome and proteome profiling of human epidermal keratinocytes to generate global and detailed images of dysregulated epidermal molecular pathways linked to loss of collagen VII.