Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer, including KRAS and Her2

Neoantigen-specific T cell responses were characterized in 4 patients with non-small cell lung cancer. Candidate neoantigens were identified by sequencing tumor and normal DNA from each patient, and ranking single nucleotide variants by expression. Multiple T cell responses were isolated, and in two patients with lung adenocarcinoma, CD4+ T cell responses to recurrent oncogenic mutations in KRAS and Her2 were identified.]]>
Inclusion: Adults with non-small cell lung cancer undergoing resections for early stage disease, who subsequently agreed to donate blood for immunology studies following surgery. Exclusions: none]]>