An E2F1-Dependent Gene Expression Program That Determines the Balance Between Proliferation and Cell Death. Rattus norvegicus

E2F1 has been shown to induce both proliferation and apoptosis. We now show that PI3K/Akt signaling regulates the balance of these events by specifically blocking expression of genes in the E2F1 apoptotic program but not the proliferative program. Keywords: PI3K dependent modulation of E2F1 gene expression measured by Affymetrix gene expression analysis Overall design: 11 samples total, two replicates each (except Sample 1 which is represented once)