p300/CBP sustains Polycomb silencing by non-enzymatic functions
收藏NIAID Data Ecosystem2026-03-14 收录
官方服务：
资源简介：
Uncropped Western blot images and immunostainings from Hunt et al.
应用场景：
创建时间：
2022-09-23
相关数据集
H2A ubiquitination is essential for Polycomb Repressive Complex 1-mediated gene regulation in Marchantia polymorpha
Polycomb repressive complex 1 (PRC1) and PRC2 are chromatin regulators maintaining transcriptional repression by depositing H2A mono-ubiquitination (H2Aub) or H3 lysine 27 tri-methylation (H3K27me3),
NIAID Data Ecosystem60
L3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-chip data].
Human MBT domain‐containing protein L3MBTL2 was found to be an integral component of a protein complex that we termed Polycomb Repressive Complex 1‐like 3 (PRC1L3) given the
NIAID Data Ecosystem40
Polycomb repression works without Siesta [ChIP]
Polycomb group proteins are essential for epigenetic repression of developmental genes. They act as multi-subunit complexes whose biochemical functions are yet to be fully characterised. One of the co
NIAID Data Ecosystem30
SAM domain polymerization links subnuclear clustering of PRC1 to silencing (Ring1B ChIP-Seq). Mus musculus
Polycomb group (PcG) proteins mediate heritable but reversible silencing of developmental regulator genes by modifying their chromatin configuration. Accumulating evidence documents a role for PcG pro
NIAID Data Ecosystem50
p300/CBP sustains Polycomb silencing by non-enzymatic functions (ChIP-seq on RNAi-treated Drosophila S2 cells). p300/CBP sustains Polycomb silencing by non-enzymatic functions (ChIP-seq on RNAi-treated Drosophila S2 cells)
Maintenance of appropriate cell states involves epigenetic mechanisms, including Polycomb group (PcG)-mediated transcriptional repression. While PcG proteins are known to induce chromatin compaction,
NIAID Data Ecosystem40
