Table_1_Moderate-to-Severe Depression Adversely Affects Lung Function in Chinese College Students.docx

Depression is known to be correlated with increased risk for chronic obstructive pulmonary disease (COPD) in middle-aged and older adults, but there is scarce evidence regarding its association with lung function among healthy adults. Thus, we aimed to assess this association by measuring the lung function and depression severity in Chinese college students. This cross-sectional study was conducted among 3,891 college students aged 16–24 years. Lung function was assessed by measuring the forced vital capacity (FVC) using a spirometer, and depression severity was evaluated using the 20-item Zung self-rating depression scale (SDS), with SDS scores of ≥40 and ≥45 indicating mild and moderate-to-severe depression, respectively. After adjusting for potential confounders, the geometric means of the FVC levels for the normal, mild depression, and moderate-to-severe depression groups were 3,446.1 (95% confidence interval [CI]: 3,418.6–3,470.3), 3,415.2 (95% CI: 3,357.7–3,473.8), and 3,351.0 (95% CI: 3271.5–3432.3), respectively (P for trend: 0.031). These results indicated that depression severity was independently correlated with lung function decline in Chinese college students. Future prospective cohort or interventional studies are needed to confirm the negative association between depressive symptoms and lung function and investigate its causality.

抑郁症与中老年人群中慢性阻塞性肺疾病（COPD）的风险增加密切相关，然而，关于其与健康成年人肺功能之间关联的证据却十分匮乏。鉴于此，本研究旨在通过测量中国大学生的肺功能和抑郁严重程度来评估二者之间的关联。本研究为一项横断面研究，纳入了3,891名16至24岁的在校大学生。肺功能通过肺量计测量最大用力肺活量（FVC）来评估，抑郁严重程度则采用20项zung自评抑郁量表（SDS）进行评定，其中SDS评分≥40分和≥45分分别代表轻度抑郁和中度至重度抑郁。在调整潜在混杂因素后，正常、轻度抑郁和中度至重度抑郁组的FVC水平几何均值分别为3,446.1（95%置信区间[CI]：3,418.6–3,470.3）、3,415.2（95% CI：3,357.7–3,473.8）和3,351.0（95% CI：3,271.5–3,432.3），差异具有统计学意义（趋势检验P值：0.031）。这些结果表明，抑郁严重程度与我国大学生肺功能下降呈独立相关。未来需要进行前瞻性队列研究或干预性研究，以确认抑郁症状与肺功能之间的负面关联，并探究其因果关系。