Additional file 8 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

Name: Additional file 8 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
Creator: Jannu, Asha Jacob; Puntambekar, Shweta S.; Lin, Peter B. C.; Moutinho, Miguel; Lamb, Bruce T.; Atwood, Brady K.; Jadhav, Vaishnavi S.; Di Prisco, Gonzalo Viana; Xu, Guixiang; Pennington, Taylor; Bissel, Stephanie J.; Oblak, Adrian L.; Zhang, Jie; Landreth, Gary E.
Published: 2020-10-29T00:00:00+08:00

Figshare2024-02-07 更新2026-04-08 收录

神经退行性机制

小鼠模型突触功能分析

数据链接：

https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Trem2_Y38C_mutation_and_loss_of_Trem2_impairs_neuronal_synapses_in_adult_mice/13160930/1 数据链接链接失效反馈

官方服务：

资源简介：

Additional file 8: Figure S2. (A) Volcano plot illustrating differentially expressed genes (P<0.05) in Trem2Y38C/Y38C versus Trem2-/- cortices. (B-C) Pathway enrichment of downregulated and upregulated genes (FDR<0.05) by Enrichr. (B) Pathway enrichment for downregulated genes indicates alteration in circadian rhythm associated pathways in Trem2Y38C/Y38C as compared to Trem2-/- mice (C) Upregulated genes show enrichment in pathways associated with protein processing in endoplasmic reticulum in Trem2Y38C/Y38C versus Trem2-/-. (B-C) P values are indicated at the end of each colored bar. Shaded gets lighter with smaller P value. Red bars represent enrichment for downregulated genes and green bars represent enrichment for upregulated genes. Sample sizes: WT mice, N = 8 (4 males, 4 females); Trem2Y38C/Y38C mice, N = 8 (4 males, 4 females); Trem2-/- mice, N = 5 (1 male, 4 females).

提供机构：

Jannu, Asha Jacob; Puntambekar, Shweta S.; Lin, Peter B. C.; Moutinho, Miguel; Lamb, Bruce T.; Atwood, Brady K.; Jadhav, Vaishnavi S.; Di Prisco, Gonzalo Viana; Xu, Guixiang; Pennington, Taylor; Bissel, Stephanie J.; Oblak, Adrian L.; Zhang, Jie; Landreth, Gary E.

创建时间：

2020-10-29