YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

We found that YTHDF2 has lower expression in GC tissues and GC cells, and promotes the growth, migration and invasion of GC cells. In addition, the analysis of clinical data found that the expression level of YTHDF2 was closely related to the stage of GC and the survival of patients with GC. RNA-seq showed that overexpression of YTHDF2 significantly reduced protein expression in the FOXC2 (Forkhead box protein C2, FOXC2) signaling pathway. The gene expression of Vector and MGC-803 cell lines overexpressing YTHDF2 were detected by RNA sequencing.