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Supplementary Table 1 from Radiation and Chemo-Sensitizing Effects of DNA-PK Inhibitors Are Proportional in Tumors and Normal Tissues

NIAID Data Ecosystem2026-05-02 收录

肿瘤放射化疗增敏

DNA-PK抑制剂

数据链接：

https://figshare.com/articles/dataset/Supplementary_Table_1_from_Radiation_and_Chemo-Sensitizing_Effects_of_DNA-PK_Inhibitors_Are_Proportional_in_Tumors_and_Normal_Tissues/26934571 数据链接链接失效反馈

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Experiment details by figure.

应用场景：

创建时间：

2024-09-04

DNA-PK抑制剂

抗癌药物研发

DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been ch

NIAID Data Ecosystem30

Identification of 6‑Anilino Imidazo[4,5‑ c ]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers

DNA-PK抑制剂

癌症放射增敏

The dominant role of non-homologous end-joining in the repair of radiation-induced double-strand breaks identifies DNA-dependent protein kinase (DNA-PK) as an excellent target for the development of r

NIAID Data Ecosystem10

Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy

DNA-PK抑制剂

癌症免疫治疗

In this work, a novel series of heterotricyclic DNA-PK inhibitors were rationally designed, synthesized, and assessed for their biological activity. In the DNA-PK biochemical assay, most compounds dis

Figshare2024-04-08 更新00

DNA-PK抑制剂

抗癌药物发现

NIAID Data Ecosystem20

Table S1 from Discovery and characterization of ZL-2201, a potent, highly selective, and orally bioavailable small-molecule DNA-PK inhibitor

DNA-PK抑制剂

癌症治疗研究

ZL-2201 anti-proliferative IC50s and ATM mutational and VAF status

Figshare2023-08-09 更新00