Data and Risk-of-Bias Materials for: The HIF-1α/VEGF Pathway as a Molecular Mediator between Glycemic Control and Retinal Ischemia in Diabetic Retinopathy: A Translational Systematic Review and Meta-Analysis

This repository contains the data extraction and risk-of-bias assessment materialssupporting the systematic review and meta-analysis "The HIF-1α/VEGF Pathway as aMolecular Mediator between Glycemic Control and Retinal Ischemia in DiabeticRetinopathy: A Translational Systematic Review and Meta-Analysis" (PROSPEROCRD420261493124), submitted to BMC Ophthalmology. Files included:1. Data_extraction_template.xlsx — the blank PECO-aligned extraction form used to collect Study Characteristics and Analysis Data.2. Extracted_dataset_113_studies.xlsx — the completed dataset for all 113 included studies (Study Characteristics and Analysis Data sheets).3. Risk_of_bias_assessment.docx — risk-of-bias ratings for all 113 included studies, assessed with the Newcastle-Ottawa Scale (clinical cohort studies), SYRCLE's Risk of Bias tool (preclinical in vivo studies), and an ad hoc, non-validated six-item methodological checklist (preclinical in vitro studies).4. Meta_analysis_input_VEGF_k8.xlsx — the input dataset for the random-effects meta-analysis of the pooled preclinical VEGF outcome (k = 8 studies). This review was conducted and reported in accordance with PRISMA 2020.