X-ray crystal structure of ADC-33 beta-lactamase in complex with ceftazidime in acyl and product forms

X-ray crystal structure of ADC-33 beta-lactamase in complex with ceftazidime in acyl and product forms Descriptor: (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ACYLATED CEFTAZIDIME, Beta-lactamase Authors: Powers, R.A, Wallar, B.J, Jarvis, H.R, Ziegler, Z.X, June, C.M. Deposit date: 2024-11-25 Release date: 2025-05-14 Last modified: 2025-07-23 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C beta-lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab ). Mbio, 16, 2025