Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors

Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors Descriptor: 1-{[(6P)-3-[(3,5-dimethoxyphenyl)methyl]-6-(4-fluoro-2-methylphenyl)-4,5-dihydro-3H-naphtho[1,2-d][1,2,3]triazol-8-yl]methyl}-3-methyl-1,3-dihydro-2H-imidazol-2-imine, WD repeat-containing protein 5 Authors: Goins, C.M, Stauffer, S.R. Deposit date: 2025-02-17 Release date: 2025-08-13 Last modified: 2026-07-08 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Development and characterization of triazole-based WDR5 inhibitors for the treatment of glioblastoma. JCI Insight, 11, 2026