Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes

A photoinduced cascade strategy is presented here for the remote functionalization of alkenes under redox neutral conditions. A broad portfolio of alkyl groups has been added to double bonds to produce, upon 1,5-HAT, remote C-centered radicals which can be harvested in the presence of O- or C-nucleophiles to efficiently form Csp3–O and Csp3–Csp2 bonds at room temperature.