Integrated_studies_of_the_development_of_natural_immunity_to_malaria_in_children_in_Kilifi_district. Integrated_studies_of_the_development_of_natural_immunity_to_malaria_in_children_in_Kilifi_district

Plasmodium falciparum var genes are a large and diverse gene family that encode PfEMP1, an important set of antigenic virulence molecules that are inserted into the surface of parasite erythrocytes. This is part of an existing collaboration with Peter Bull and Vandana Thathy (KEMRI) to measure expression of var genes in clinical isolates from Kilifi, Kenya, and to identify genes that are associated with severe malaria and low levels of host immunity (Warimwe et at 2009 PNAS). Here we will be carrying out whole genome sequencing of isolates being used in Kenya for phenotyping analysis. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/