Gut microbiota and fecal metabolites in rat offspring raised by letrozole induced hyperandrogenism dam

Gut microbiota (GM) and fecal metabolics are significantly changes in autism individuals and animal models. In this study, we performed 16S rRNA gene sequencing and untargeted metabolomics on fecal samples from offsprings raised by letrozole induced hyperandrogenism dams (LTZ rats). Then we analyzed key metabolites in KEGG database to reveal the possible mechanism. Male and female rats were analyzed separately.