miRNA profiling of biliary intraepithelial neoplasia reveals step-wise tumorigenesis in distal cholangiocarcinoma via the miR-451a/ATF2 axis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147969
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资源简介：
Distal cholangiocarcinoma (dCCA) is a biliary tract cancer with dismal prognosis and is often preceded by biliary intraepithelial neoplasia (BilIN) as a non-invasive precursor lesion. We found that miR-451a is downregulated in dCCA. Overexpression of mimic-451a in the CCA cell line SNU478 revealed multiple downregulated genes and potential miR-451a candidate targets. The CCA cell line SNU478 was transfected with AllStars control or mimic-451a miRNA in quadruplicates and cultured for 48 h. Thereafter, cells were harvested and RNA was isolated followed by human Clariom_D microarray analysis.
创建时间：
2020-09-03
