Integrated analysis of transcriptome and proteome reveal that PDCoV infection induces autophagy-dependent ferroptosis to facilitate viral replication

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes severe diarrhea in swine industries worldwide. However, the interactions between PDCoV and host cells remain poorly understood. We demonstrated that autophagy and ferroptosis were induced upon PDCoV infection, and that inhibition of autophagy significantly suppressed the induction of PDCoV-induced ferroptosis, which decreases the viral proliferation.