K63polyUb-cIAP1,2 ubiquitinates TRAF3

cIAP1,2 targets NIK for ubiquitination and degradation under unstimulated conditions but redirects its destructive action towards TRAF3 in response to receptor signals. K63polyUb-cIAP1,2 catalyses K48-linked polyubiquitination of TRAF3 leading to signal-induced TARF3 degradation.

cIAP1,2在非刺激条件下靶向NIK进行泛素化和降解，但在受体信号刺激下，其破坏作用转向TRAF3。K63polyUb-cIAP1,2催化TRAF3的K48连接多泛素化，导致信号诱导的TARF3降解。